The selective increase in tumor blood flow under angiotensin II-induced hypertension was observed to be the result of passive vascular beds irresponsive to angiotensin II. We investigated whether or not increased tumor blood flow resulting from angiotensin II-induced hypertension could be recognized on angiographic findings. Angiography under angiotensin II-induced hypertension was performed in 51 patients with various cancers, and angiographic findings indicating increased tumor vascularity were recognized in 40 (78.4%) of them. Based on the assumption that the increase in tumor oxygen tension was brought about by increased tumor blood flow, the possibility of utilizing this phenomenon in hyperbaric oxygenation radiotherapy was suggested.
Tomura, Saito, Hirata, Matsudaira, Tamakawa, Kato, , , (). Tumor vascularity under angiotensin II-induced hypertension–angiographic observations. Radiation medicine, ;4(2):60-6. https://www.ncbi.nlm.nih.gov/pubmed/3797701