Hyperbaric oxygen therapy in necrotizing soft tissue infections.
Abstract: Surgical debridement and antibiotics are the mainstays of therapy for patients with necrotizing soft tissue infections (NSTIs), but hyperbaric oxygen therapy (HBO) is often used as an adjunctive measure. Despite this, the efficacy of HBO remains unclear. We...
Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials.
Abstract: There is a controversy about the efficacy of hyperbaric oxygen (HBO) therapy for the treatment of autism. This study systematically reviews the current evidences for treating of autism with HBO therapy. According to PRISMA guidelines for a systematic review,...
Hyperbaric oxygen – its mechanisms and efficacy
Principal mechanisms of HBO2 are based on intracellular generation of reactive species of oxygen and nitrogen. Reactive species are recognized to play a central role in cell signal transduction cascades and the discussion will focus on these pathways. Systematic reviews and randomized clinical trials support clinical use of HBO2 for refractory diabetic wound healing and radiation injuries; treatment of compromised flaps and grafts and ischemia-reperfusion disorders is supported by animal studies and a small number of clinical trials, but further studies are warranted.
Hyperbaric oxygen treatment in the experimental spinal cord injury model.
Abstract: Spinal cord trauma is a major cause of mortality and morbidity. Although no known treatment for spinal cord injury exists, a limited number of effective treatment modalities and procedures are available that improve secondary injury. Hyperbaric oxygen (HBO)...
Hyperbaric oxygen treatment in the experimental spinal cord injury model.
Abstract: Spinal cord trauma is a major cause of mortality and morbidity. Although no known treatment for spinal cord injury exists, a limited number of effective treatment modalities and procedures are available that improve secondary injury. Hyperbaric oxygen (HBO)...
Full thickness burns over bilateral patella tendons – adjunctive Hyperbaric Oxygen Therapy and Negative Pressure Wound Therapy for wound bed preparation and improved graft take.
Abstract: Chong, Ooi, Kok, Tan, , , , , (2011). Full thickness burns over bilateral patella tendons - adjunctive Hyperbaric Oxygen Therapy and Negative Pressure Wound Therapy for wound bed preparation and improved graft take. Annals of the Academy of Medicine,...
Cardiorespiratory effects of change in posture after spinal anesthesia with hyperbaric bupivacaine.
Abstract: Spinal anesthesia is a special regional anesthetic technique that is applied in lower limb orthopedic and other surgical procedures made below the transverse umbilical line, which is able to produce a neuraxial central block. The patient's position, together...
What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics.
Abstract: This study tested hyperbaric oxygen (HBO) as an adjunct to surgery and antibiotics in the treatment of bisphosphonate-related osteonecrosis of the jaw (ONJ) and evaluated its effects on gingival healing, pain, and quality of life. The investigators...
The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.
Abstract: Benzotriazine-N-oxide bioreductive prodrugs such as tirapazamine and its improved analogue CEN-209 (SN30000) have potential for exploiting hypoxia in tumors. Here, we test the hypothesis that the 2-nitroimidazole EF5, in clinical development for both...