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Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle.

by Extivita | Aug 21, 2015 | Cancer

Abstract: The naturally occurring isotope of hydrogen ((1)H), deuterium ((2)H), could have an important biological role. Deuterium depleted water delays tumor progression in mice, dogs, cats and humans. Hydratase enzymes of the tricarboxylic acid (TCA) cycle control...

Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferation.

by Extivita | Nov 30, 2005 | Carcinoma

Abstract: Hyperbaric oxygenation (HBO) therapy is the administration of 100%-inhaled oxygen to patients at increased atmospheric pressure. We used an in vitro model to examine the effects of HBO on mammary cell proliferation. Normal mammary epithelia, primary tumor...

Flow cytometric measurements of deoxyribonucleic acid ploidy and proliferative activity for evaluating malignant potential of human bladder cancers.

by Extivita | Jan 1, 1995 | Carcinoma

Abstract: Flow cytometric bromodeoxyuridine/deoxyribonucleic acid (DNA) bivariate analysis for transitional cell carcinoma of the human bladder tumor was performed to evaluate whether or not this technique can determine the malignant potential of these tumors. In...

Lack of recovery from oxygen-induced damage to colony formation and DNA synthesis in senescent human diploid fibroblasts.

by Extivita | Sep 14, 1987 | Cancer

Abstract: The colony formation and DNA synthesis of cultured human fibroblasts were inhibited under hyperbaric oxygen. When maintained in a growth-arrested state for a few days after oxygen exposure, early passage diploid and SV-40-transformed cells repaired the...

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    Hyperbaric Oxygen Therapy (HBOT) Clinic located in Research Triangle Park, North Carolina (RTP, Raleigh, Durham, Chapel Hill).