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Hyperbaric oxygen treatment reverses radiation induced pro-fibrotic and oxidative stress responses in a rat model.

by Extivita | Jun 30, 2016 | Chronic Wounds

Abstract: Radiotherapy is effective in the treatment of tumors in the pelvic area but is associated with side effects such as cystitis and proctitis. Hyperbaric Oxygen Therapy (HBOT) has emerged as a treatment modality for radiation-induced side effects. In a rat...

Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-κB Signaling Pathway.

by Extivita | Jan 27, 2016 | Rheumatoid Arthritis, Traumatic Brain Injury (TBI)

Abstract: The aim of this study was to investigate the efficacy of hyperbaric oxygen in secondary brain injury after trauma and its mechanism in a rat model. A rat model of TBI was constructed using the modified Feeney’s free-fall method, and 60 SD rats were...

Effects of Hyperoxia on Oxygen-Related Inflammation with a Focus on Obesity.

by Extivita | Apr 29, 2015 | Chronic Wounds

Abstract: Several studies have shown a pathological oxygenation (hypoxia/hyperoxia) on the adipose tissue in obese subjects. Additionally, the excess of body weight is often accompanied by a state of chronic low-degree inflammation. The inflammation phenomenon is a...

Relative neuroprotective effects hyperbaric oxygen treatment and TLR4 knockout in a mouse model of temporary middle cerebral artery occlusion.

by Extivita | Jan 7, 2015 | Stroke

Abstract: To examine the effects of hyperbaric oxygen (HBO) therapy and knockout of toll-like receptor 4 (TLR4) on the outcome of temporary middle cerebral artery occlusion (MCAO) in a mouse model. MCAO was induced in anesthetized male C57Bl/6 mice (WT) and TLR4...

The effects of hyperbaric oxygen on macrophage polarization after rat spinal cord injury.

by Extivita | Nov 30, 2014 | Spinal Cord Injuries

Abstract: The immunoreactive responses are a two-edged sword after spinal cord injury (SCI). Macrophages are the predominant inflammatory cells responsible for this response. However, the mechanism underlying the effects of HBOT on the immunomodulation following SCI...
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    Hyperbaric Oxygen Therapy (HBOT) Clinic located in Research Triangle Park, North Carolina (RTP, Raleigh, Durham, Chapel Hill).