Inside Bryan Johnson’s $2M Longevity Regimen—and What It Means for You
Image of Bryan Johnson next to his home ZEUGMA hyperbaric chamber (2.0 ATA) made by HPO TECH
Biohacking, Billionaires & Breakthroughs
What if you could reverse aging—not with surgery or supplements—but with something as elemental as oxygen?
That’s what tech entrepreneur and wellness pioneer Bryan Johnson is exploring. In his $2 million-a-year effort to reverse his biological age, Johnson has identified Hyperbaric Oxygen Therapy (HBOT) as one of his most impactful interventions.
At Extivita, where we specialize in science-based, physician-directed regenerative therapies, we see firsthand the transformative potential of HBOT every day. Here’s how Johnson’s results align with emerging clinical research—and how you can begin exploring this breakthrough without billionaire-level spending.
Bryan Johnson’s Regimen and the Role of HBOT
Johnson’s daily blueprint includes sleep scoring, biomarker tracking, and a nutrition program worthy of a clinical trial. But when he spoke publicly about the biggest “unlock” in his health protocol, it wasn’t a supplement or surgery—it was HBOT.
He completed a 90-day intensive protocol in a custom-built ZEUGMA hyperbaric chamber, designed for elite-level performance and data monitoring [2][3]. While the chamber’s design offers precision control, it’s the therapy itself—oxygen under pressure—that delivers the biological benefits.
“HBOT was one of the biggest unlocks in my brain performance.” — Bryan Johnson
What Is HBOT?
Photo of Extivita’s HBOT chamber interior—clean, welcoming, and pressurized setting.
HBOT involves inhaling 100% oxygen in a sealed, pressurized chamber. This process temporarily increases the amount of oxygen dissolved in the blood plasma, allowing oxygen to reach tissues and organs that may have reduced circulation.
Key physiological responses include:
- Enhanced wound and tissue repair
- Boosted mitochondrial activity
- Reduction of oxidative stress and inflammation
- Stimulation of neurogenesis and angiogenesis
What Does the Research Say?
In a 2020 study, Tel Aviv researchers found that after 60 sessions of HBOT over 90 days:
- Telomere length increased by 20–37%
- Senescent cells decreased by 11–37%
- Cognitive performance improved measurably
This was the first documented trial to show that a non-pharmaceutical protocol can reverse cellular aging markers in healthy adults.
Other studies suggest HBOT helps with:
- Traumatic brain injury recovery
- Post-stroke recovery
- Anxiety and PTSD symptom reduction
- Enhanced focus, memory, and energy
“This is the first study to show that a non-pharmacological intervention can reverse cellular aging in humans.” — Efrati et al., 2020
Photo of Extivita’s team guiding a new visitor during a Personalized Wellness Visit .
At Extivita, we recognize the power of oxygen as a biological medicine. And while we’re excited to see innovators like Johnson validating HBOT on a global stage, our focus remains on making this therapy accessible, evidence-based, and personalized.
We offer a wide range of integrative therapies including:
Book Your Free Personalized Wellness Visit
Curious about HBOT?
Take the first step with a no-cost, no-pressure Personalized Wellness Visit at Extivita.
See our facility, explore your options, and create a custom plan tailored to your health goals.
The Future of Regenerative Medicine Is Already Here
Oxygen is one of the most fundamental healing tools available to us. Whether you’re a peak-performance seeker like Bryan Johnson or someone navigating recovery, aging, or brain fog—HBOT could offer significant support.
And at Extivita, it’s already available.
References
- MSN Health. “Spending $2M to Live Forever: Biohacker Shares Oxygen Therapy Breakthrough.” MSN, July 2023. Available at: https://www.msn.com/en-us/health/medical/spending-2m-to-live-forever-biohacker-shares-oxygen-therapy-breakthrough/ar-AA1FZvT1
- HPO Tech. “Bryan Johnson’s HBOT Experiment with the ZEUGMA Hyperbaric Chamber.” HPO Tech Blog, December 10, 2024. Available at: https://www.hpotech.com/2024/12/10/bryan-johnson-hbot-experiment-with-the-zeugma-hyperbaric-chamber/
- HPO Tech. “60 Sessions Later, We Have the Results: Bryan Johnson’s HBOT Experiment.” HPO Tech Blog, April 24, 2025. Available at: https://www.hpotech.com/2025/04/24/60-sessions-later-we-have-the-results-bryan-johnson-hbot-experiment-with-the-zeugma-hyperbaric-chamber/
- Johnson, Bryan. “I Tried HBOT—Here’s What It Did to My Brain.” Blueprint Blog, June 4, 2025. https://www.blueprint.bio/blog/i-tried-hbot-heres-what-it-did-to-my-brain
- The Economic Times. “Bryan Johnson Claims He Has the Biology of a 10-Year-Old.” Panache, June 3, 2025. https://economictimes.indiatimes.com
- Efrati, S., et al. “Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.” Aging, vol. 12, no. 22, 2020, pp. 22445–22456. DOI: https://doi.org/10.18632/aging.202188
FDA Disclaimer
HBOT is FDA-approved for 13 conditions, such as decompression sickness and chronic wounds. Its use for aging, cognitive enhancement, PTSD, and similar conditions is off-label and not FDA-approved.
At Extivita, all off-label uses require:
- Full disclosure of non-FDA approval
- Signed informed consent
- Medical evaluation by a licensed provider