HBOT Research

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Explore our database on Hyperbaric Oxygen Therapy (HBOT) Research below.

Extivita maintains an extensive research & publication database for various diseases and therapies such as Hyperbaric Oxygen Therapy, Neurofeedback, Nutritional IV Therapy, Infrared Sauna, and Pulsed Electromagnetic Field Therapy.

For a complete list of indications treated at Extivita, explore the conditions we treat.

 

Hyperbaric Oxygen Pretreatment Improves Cognition and Reduces Hippocampal Damage Via p38 Mitogen-Activated Protein Kinase in a Rat Model.

To investigate the effects of hyperbaric oxygen (HBO) pretreatment on cognitive decline and neuronal damage in an Alzheimer’s disease (AD) rat model. Rats were divided into three groups: normal saline (NS), AD, and HBO+AD. In the AD group, amyloid ฮฒ peptide (Aฮฒ)โ‚โ‚‹โ‚„โ‚€ was injected into the hippocampal CA1 region of the brain. NS rats received NS injection. In the HBO+AD group, rats received 5 days of daily HBO therapy following Aฮฒโ‚โ‚‹โ‚„โ‚€ injection. Learning and memory capabilities were examined using the Morris water maze task. Neuronal damage and astrocyte activation were evaluated by hematoxylin-eosin staining and immunohistochemistry, respectively. Dendritic spine density was determined by Golgi-Cox staining. Tumor necrosis factor-ฮฑ, interleukin-1ฮฒ, and interleukin-10 production was assessed by enzyme-linked immunosorbent assay. Neuron apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling. Protein expression was examined by western blotting. HBO pretreatment improves cognition and reduces hippocampal damage via p38 MAPK in AD rats.

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