Parkinson’s Disease (PD) is a neurogenerative disease characterized by severe motor and non-motor symptoms(1). The prevalence of PD in the United States is growing but is currently estimated to be 572 per 100,000 with the risk of PD increasing with age(2, 3).
The root cause of PD is believed to involve genetic and environmental factors, toxin exposure, oxidative stress, neuroinflammation, hypoxia, metabolic dysfunction, and ubiquitin–proteasome system dysfunction. The outcome is clusters of misfolded proteins called Lewy bodies that cause serious damage to brain cells, especially dopamine-producing neurons in the substantia nigra (SN) that project to the striatum(4).
This damage is likely the cause of the severe motor symptoms (slow movement, muscle rigidity, tremors, posture problems) and non-motor symptoms (cognitive dysfunction, sleep issues, fatigue) that are characteristic of PD(5, 6). The combination of these symptoms significantly decreases quality of life, especially the categories of physical function and mental health(7).
Extivita Therapies for Parkinson’s Disease: