To determine the safety of a hyperbaric oxygen therapy (HBOT) protocol and its influence on the healing of uncomplicated open and incisional wounds in dogs. Prospective, controlled experimental study. Adult dogs (n = 10). Two 2 × 2-cm open wounds and two 3-cm-long full-thickness dermal incisions were created on the dorsum of each dog. Dogs in the hyperbaric oxygen treatment group (HBO) received HBOT once daily (1.7 atmospheres absolute [ATA], 30 minutes on day 1; 2.0 ATA, 40 minutes on days 2-7) for 7 consecutive days, and dogs in the control group (CON) received standardized wound care. Dogs were monitored during HBOT for adverse side effects. Total wound area, percentage epithelialization, and percentage contraction were compared for the open wounds. Subjective wound scores were compared for the open and incisional wounds. Biopsies of both wound types were taken and used to determine histopathology scores. Bacterial cultures were completed on open wounds.
Latimer, Lux, Roberts, Drum, Braswell, Sula (2018). Effects of hyperbaric oxygen therapy on uncomplicated incisional and open wound healing in dogs. Veterinary surgery : VS, 2018 Aug;47(6):827-836. https://www.ncbi.nlm.nih.gov/pubmed/30051475