Wounds refractory to standard treatment in patients with thromboangiitis obliterans (TAO, Buerger’s disease) are associated with amputation, other morbidity and mortality. The purpose of this study was to investigate the effect of hyperbaric oxygen treatment (HBOT) in patients with TAO. Ninety-seven patients with TAO with ischaemic wounds treated between January 2007 and July 2016 were included in this dual-centre, non-randomised, retrospective study. Patients receiving HBOT in addition to conventional treatment were enrolled in an HBOT group ( = 47) and those receiving conventional treatment alone in a non-HBOT group ( = 50). All patients were Rutherford grade III at the time of enrolment. Significant improvement in the major amputation rate was observed in the HBOT group 10 months after starting treatment (2/47 vs. 13/50, = 0.007). Numbers of patients progressing to Rutherford grade I (27/47 vs. 17/50, = 0.035), numbers of patients healing completely (21 vs. 11, = 0.031 and pain scores (visual analogue scale; 1, range 0-8 vs. 6, range 0-9, < 0.001) were also significantly improved in the HBOT group. The addition of HBOT to conventional treatment in TAO patients with non-healing ischaemic wounds and severe extremity pain, conferred significant benefits in terms of wound healing and rest pain control. Multi-centre, prospective, randomized studies with blinded outcome analysis are now needed to elicit more reliable results.

Hemsinli, Altun, Kaplan, Yildirim, Cebi (2018). Hyperbaric oxygen treatment in thromboangiitis obliterans: a retrospective clinical audit. Diving and hyperbaric medicine, 2018 Mar;48(1):31-35. https://www.ncbi.nlm.nih.gov/pubmed/29557099