We describe a case of systemic lupus erythematosus (SLE) with enteritis and peritonitis who later developed pneumatosis cystoides intestinalis (PCI). A 35-year-old woman with SLE relapsed with enteritis and peritonitis. Prednisolone (PSL) effectively improved her symptoms. However, 6 weeks later, she developed PCI. Tapering of PSL, administration of intravenous cyclophosphamide, prokinetic agents and antibiotics, bowel rest with intravenous hypernutrition therapy and hyperbaric oxygen therapy successfully improved PCI. Although PCI is a rare complication of SLE, the present case suggests that lupus enteritis could be a risk factor for PCI, and that high-dose PSL could cause additional insult to PCI.

Mizoguchi, Nanki, Miyasaka, , , , , , (2008). Pneumatosis cystoides intestinalis following lupus enteritis and peritonitis. Internal medicine (Tokyo, Japan), 2008 ;47(13):1267-71. https://www.ncbi.nlm.nih.gov/pubmed/18591854