Western diamondback rattlesnake envenomation is usually managed by administration of neutralizing antivenom. The development of compartment syndrome is a rare complication that has sparked considerable debate regarding medical vs. surgical management. We report a case of compartment syndrome resulting from a rattlesnake envenomation, which responded to large doses of neutralizing antivenom given concomitantly with mannitol and hyperbaric oxygen. This regimen obviated the need for surgical fasciotomy and its associated morbidity.

Gold, Barish, Dart, Silverman, Bochicchio, , , , (2003). Resolution of compartment syndrome after rattlesnake envenomation utilizing non-invasive measures. The Journal of emergency medicine, 2003 Apr;24(3):285-8. https://www.ncbi.nlm.nih.gov/pubmed/12676299