Neuropathy

Neuropathic pain also sometimes called nerve pain (NP) is a prevalent and etiologically complex disease defined as central or peripheral nervous system pain caused by direct injury or dysfunction (1). NP is chronic and progressive, often characterized by continuous or intermittent, as burning or coldness, “pins and needles” sensations, numbness and itching. Causes of NP are numerous and range from metabolic (i.e. diabetes), infectious (i.e. post herpetic neuralgia), autoimmune (i.e. multiple sclerosis), nervous (I.e. trigeminal neuralgia), cancerous, to vascular (i.e. stroke)(1).

Extivita Therapies for Neuropathy:

  • Hyperbaric Oxygen Therapy
  • Neurofeedback
  • Nutritional IV Therapy
  • Pulsed Electromagnetic Field Therapy

Neuropathy

Neuropathic pain also sometimes called nerve pain (NP) is a prevalent and etiologically complex disease defined as central or peripheral nervous system pain caused by direct injury or dysfunction (1). NP is chronic and progressive, often characterized by continuous or intermittent, as burning or coldness, “pins and needles” sensations, numbness and itching. Causes of NP are numerous and range from metabolic (i.e. diabetes), infectious (i.e. post herpetic neuralgia), autoimmune (i.e. multiple sclerosis), nervous (I.e. trigeminal neuralgia), cancerous, to vascular (i.e. stroke)(1).

Extivita Therapies for Neuropathy:

  • Hyperbaric Oxygen Therapy
  • Neurofeedback
  • Nutritional IV Therapy
  • Pulsed Electromagnetic Field Therapy

Extivita Therapies Neuropathic Pain Recovery:

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy

Neurofeedback

Hyperbaric Oxygen Therapy

Supplements

Hyperbaric Oxygen Therapy

Nutritional IV Therapy

Pulsed Electromagnetic Field Therapy (PEMF)

Pulsed Electromagnetic Field Therapy

Hyperbaric Oxygen Therapy (HBOT):

Hyperbaric Oxygen Therapy - Chapel Hill

Hyperbaric oxygen therapy (HBOT) has been shown to be effective in the late chronic stage of strokes by multiple studies. After receiving 40-60 HBOT treatments, one study found that 86% of the patients experienced clinically significant improvements in all cognitive domains. This included memory, executive function, attention, information processing speed, and motor skills (4).

Additional studies report similar findings of improved ADLs (activities of daily living), brain metabolism, and quality of life (5,6). Brain scans showed that the damaged locations of the brain were significantly healed and reactivated in more than half of the patients (6). HBOT improves stroke symptoms by healing brain cells that were initially damaged by the stroke as well as stimulating the growth of new brain cells (4,7).

Effects of HBOT on Stroke:

Grows New Blood Vessels

New Blood Vessel Formation

Hyperbaric oxygen therapy stimulates the formation of new blood vessels, healing injured tissues that were unable to get nutrients and oxygen.

Increases Stem Cell Production

Increased Stem Cell Activity

Hyperbaric oxygen therapy mobilizes stem progenitor cells (SPCs) from the bone marrow, creating the opportunity for tissue regeneration.

Decreases Inflammation

Decreased Inflammation

Hyperbaric oxygen therapy reduces systemic inflammation by increasing anti-inflammatory gene expression and decreasing proinflammatory genes.

Hyperbaric Oxygen Therapy - Chapel Hill

Neurofeedback:

Research has been able to isolate the location of brain activity that contributes to physical and emotional aspects of chronic pain. Neurofeedback operates by targeting those areas and has been shown to be manipulated for pain relief without side effects.

Learn more about Neurofeedback…

IV Therapy:

One of the causes of PN has been attributed to nutritional deficiencies as well as infections. Myers cocktail, which is full of B vitamins like B12, may help nerve pain associated with nutrient deficiencies as well as in patients with diabetes associated neuropathy (8). Vitamin C (in Myers cocktail) and glutathione can also help as antioxidants as peripheral nerves are susceptible to damage by toxins (8, 9).

Learn more about IV Therapy…

Hyperbaric Oxygen Therapy - Chapel Hill

Hyperbaric Oxygen Therapy - Chapel Hill

Pulsed Electromagnetic Field Therapy (PEMF):

PEMF uses safe, low frequency (not like cell phones) signals to stimulate capillaries resulting in therapeutic effects (13). Improving neural microcirculation can around damaged nerves can reduce pain, inflammation and reduce further damage (13, 14).


Learn more about PEMF Therapy…

Recent Stroke News & Research:

Neurofeedback Treatments Rated Effective in ADHD

Neurofeedback Treatments Rated Effective in ADHD

Neurofeedback treatments for attention-deficit/hyperactivity disorder (ADHD) demonstrate medium to large effect sizes and remission rates between 32% and 47%, according to a study published online in the journal Applied Psychophysiology and Biofeedback. “[S]tandard…

read more

References
  1. Ding Y, Yao P, Hong T, Han Z, Zhao B, Chen W. The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain. J Headache Pain. 2017;18(1):51.
  2. Gibbons, Carlee R et al. “Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain.” Brain research vol. 1537 (2013): 111-6. doi:10.1016/j.brainres.2013.08.050
  3. Gu, N. , Niu, J. , Liu, W. , Sun, Y. , Liu, S. , Lv, Y. , Dong, H. , Song, X. and Xiong, L. (2012), Hyperbaric oxygen therapy reduces chronic pain. EJP, 16: 1094-1105. doi:10.1002/j.1532-2149.2012.00113.x
  4. Han, Guang et al. “The effects of hyperbaric oxygen therapy on neuropathic pain via mitophagy in microglia.” Molecular pain vol. 13 (2017): 1744806917710862. doi:10.1177/1744806917710862
  5. Liu, Yong-Da et al. “Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway.” American journal of translational research vol. 9,5 2629-2638. 15 May. 2017
  6. Y Zhang, AL Brewer, JT Nelson, PT Smith, DY Shirachi, RM Quock (2019), Hyperbaric oxygen produces a nitric oxide synthase-regulated anti-allodynic effect in rats with paclitaxel-induced neuropathic pain. Brain Research, 1711:41-47. doi.org/10.1016/j.brainres.2019.01.009
  7. Zhao BS, Meng LX, Ding YY, Cao YY. Hyperbaric oxygen treatment produces an antinociceptive response phase and inhibits astrocyte activation and inflammatory response in a rat model of neuropathic pain. J Mol Neurosci. 2014;53(2):251–261.
  8. Staff, Nathan P, and Anthony J Windebank. “Peripheral neuropathy due to vitamin deficiency, toxins, and medications.” Continuum (Minneapolis, Minn.) vol. 20,5 Peripheral Nervous System Disorders (2014): 1293-306. doi:10.1212/01.CON.0000455880.06675.5a
  9. Kumar, Neeraj. “Neurologic presentations of nutritional deficiencies.” Neurologic clinics vol. 28,1 (2010): 107-70. doi:10.1016/j.ncl.2009.09.006
  10. Prinsloo, S., Novy, D., Driver, L., Lyle, R., Ramondetta, L., Eng, C., McQuade, J., Lopez, G. and Cohen, L. (2017), Randomized controlled trial of neurofeedback on chemotherapy‐induced peripheral neuropathy: A pilot study. Cancer, 123: 1989-1997. doi:10.1002/cncr.30649
  11. Bismuth, Julie et al. “Relieving peripheral neuropathic pain by increasing the power-ratio of low-β over high-β activities in the central cortical region with EEG-based neurofeedback: Study protocol for a controlled pilot trial (SMRPain study).” Neurophysiologie clinique = Clinical neurophysiology vol. 50,1 (2020): 5-20. doi:10.1016/j.neucli.2019.12.002
  12. Hassan, Muhammad Abul et al. “The mechanism of neurofeedback training for treatment of central neuropathic pain in paraplegia: a pilot study.” BMC neurology vol. 15 200. 13 Oct. 2015, doi:10.1186/s12883-015-0445-7
  13. Graak, Vinay et al. “Evaluation of the efficacy of pulsed electromagnetic field in the management of patients with diabetic polyneuropathy.” International Journal of Diabetes in Developing Countries 29 (2009): 56 – 61.
  14. Gao, Yueming et al. “Changes in nerve microcirculation following peripheral nerve compression.” Neural Regeneration Research (2013): 1041–1047.