To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn’s disease. A total of 29 subjects with refractory Crohn’s disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn’s disease. A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn’s disease healing rate was 65%. Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn’s disease.

Feitosa, Féres Filho, Tamaki, Perazzoli, Bernardes, Parra, Rocha, Féres (2016). Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn’s disease. Acta cirurgica brasileira, 2016 ;31 Suppl 1():19-23. https://www.ncbi.nlm.nih.gov/pubmed/27142900