Between 1979 and 1982, thirty-eight patients with chronic non-hematogenous osteomyelitis were treated by local débridements of the wound, prolonged parenteral administration of antibiotics, and an average of forty-eight once-a-day treatments with hyperbaric oxygen. Of these thirty-eight patients, thirty-four remained free of clinical signs of osteomyelitis for an average of thirty-four months (range, twenty-four to fifty-nine months) after this regimen of treatment. Only four of the thirty-eight patients had been free of clinical signs of osteomyelitis for as long as three months during the two years preceding this treatment. Three of the four failures of treatment were evident within one month after treatment. This method of treatment appears to prolong the infection-free interval of patients with chronic non-hematogenous osteomyelitis.
Davis, Heckman, DeLee, Buckwold, , , , , (1986). Chronic non-hematogenous osteomyelitis treated with adjuvant hyperbaric oxygen. The Journal of bone and joint surgery. American volume, 1986 Oct;68(8):1210-7. https://www.ncbi.nlm.nih.gov/pubmed/3771602