Evaluate the application of Hyperbaric Oxygen Therapy (HBO) in patients with Crohn’s disease (CD) refractory to pharmacologic therapy, who developed abdominal, anorectal or skin complications. Fourteen selected patients with refractory CD and treated at the School of Medicine of Ribeirao Preto, University of Sao Paulo (FMRP-USP) and at the Center of Hyperbaric Medicine, São Paulo Hospital (CEMEHI) were submitted to HBO. Of the 14 patients evaluated, 11 had a satisfactory response. HBO has shown benefits in patients with CD refractory to pharmacologic therapy.

Iezzi, Feitosa, Medeiros, Aquino, Almeida, Parra, Rocha, Féres, (2011). Crohn’s disease and hyperbaric oxygen therapy. Acta cirurgica brasileira, 2011 ;26 Suppl 2():129-32. https://www.ncbi.nlm.nih.gov/pubmed/22030829