Abstract:
We previously reported in healthy volunteers that a cantaloupe melon extract chemically combined with wheat gliadin (melon extract/gliadin) and containing SOD, catalase and residual glutathione peroxidase (GPx), protected against DNA strand-break damage induced by hyperbaric oxygen (HBO), a well-established model of DNA damage resulting from oxidative stress. Aortic cross-clamping is a typical example of ischemia/reperfusion injury-related oxidative stress, and therefore we investigated whether this melon extract/gliadin would also reduce DNA damage after aortic cross-clamping and reperfusion. Prospective, randomized, controlled experimental study. Animal laboratory. 18 anesthetized, mechanically ventilated and instrumented pigs.
Kick, Hauser, Bracht, Albicini, Oter, Simon, Ehrmann, Garrel, (2007). Effects of a cantaloupe melon extract/wheat gliadin biopolymer during aortic cross-clamping. Intensive care medicine, 2007 Apr;33(4):694-702. https://www.ncbi.nlm.nih.gov/pubmed/17237934