Cutaneous microcirculation is responsible for thermoregulatory exchange, excretion of several substances such as water and minerals and protection against external stressors such as heat and cold. Thus skin microcirculation plays a significant role in human body homeostasis as well as in several diseases that may affect the whole organism, including cancer, allergic reaction, dermatosis and dermatites. Two vascular plexuses compose the skin microvasculature: subdermal and dermic. Therefore this anatomical configuration allows endothelial function assessment by laser Doppler flowmetry.

C. Camargo, R. Gemperli (2018). Chapter 47 – Endothelial Function in Skin Microcirculation. Endothelium and Cardiovascular Diseases. Vascular Biology and Clinical Syndromes
2018, Pages 673-679. https://doi.org/10.1016/B978-0-12-812348-5.00047-7