Chronic skin ulcers require extensive, systemic differential diagnosis; thus, they are difficult to diagnose and treat. Transient or persistent hypercoagulable states are among the rare causes of skin ulcers. Here, we present the case of a 27-year-old woman patient with recurrent, nonhealing skin ulcers of 8 years’ duration, who had been treated unsuccessfully with various medications under different diagnoses at different clinics. On admission, a skin biopsy demonstrated occlusive vasculopathy, and the search for an inherited hypercoagulable state revealed a heterozygous factor V Leiden mutation. The patient was treated with anticoagulants and hyperbaric oxygen. On treatment, the skin lesions healed and did not recur.

Kayatas, Cebeci, Karatoprak, Benzer, Demirtunç, Demirkesen, , , (2013). Factor V Leiden mutation-related chronic skin ulcers. The international journal of lower extremity wounds, 2013 Mar;12(1):35-8. https://www.ncbi.nlm.nih.gov/pubmed/23446370