Multiple Sclerosis (MS) is a chronic, recurrent and progressive illness with no cure. On the basis of speculative pathophysiology, it has been suggested that Hyperbaric Oxygen Therapy (HBOT) may slow or reverse the progress of the disease. The object of this review was to evaluate the efficacy and safety of HBOT in the treatment of MS. We searched the Cochrane MS Group trials register (July 2002), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 2, 2002), MEDLINE (January 1966 to October 2002) and the National Library of Medicine (NLM) database (July 2002), along with specialised hyperbaric resources and handsearching of relevant journals and proceedings. All randomised, controlled trials involving a comparison between HBOT and a sham therapy in MS were evaluated.

Bennett, Heard, , , , , , , (2004). Hyperbaric oxygen therapy for multiple sclerosis. The Cochrane database of systematic reviews, 2004 ;(1):CD003057. https://www.ncbi.nlm.nih.gov/pubmed/14974004