Inhalation of pressurized 100% oxygen is a helpful adjunctive treatment for certain patients, because the increased oxygen carried by the blood to the tissue enhances new growth of microcirculation and, thus, healing. Patients with tissue breakdown after radiation therapy, refractory osteomyelitis, gas gangrene, soft-tissue infection with necrosis from mixed aerobic and anaerobic organisms, crush injuries resulting in acute ischemia, and compromised skin grafts or non-healing wounds are likely to benefit from hyperbaric oxygen therapy.

Cohn, , , , , , , , (1986). Hyperbaric oxygen therapy. Promoting healing in difficult cases. Postgraduate medicine, 1986 Feb;79(2):89-92. https://www.ncbi.nlm.nih.gov/pubmed/3511470