This report describes experience with radiation therapy in hyperbaric oxygen in 201 patients with squamous carcinoma arising in the mobile portion of tongue (anterior 2/3), oropharynx, hypopharynx, and supraglottic larynx, treated between the years 1964 and 1980. Although not statistically different, the overall 5-year determinate survival figures of 35% for all patients with tumors arising in the hypopharynx, 87.5% for Stage I and II, 55% for Stage III, and 27.1% for Stage IV supraglottic carcinoma were perceptibly better than those obtained in a contemporary but not randomly controlled series of patients treated in air at Royal Adelaide Hospital from 1970 to 1980. The results obtained for tumors arising in the oropharynx and mobile portion of tongue however were found to be very similar to those achieved in air. The results achieved in this series are discussed in the context of experience at other centers and the role of randomly controlled clinical studies in evaluating new treatment modalities is emphasized.

Denham, Yeoh, Wittwer, Ward, Ahmad, Harvey (1987). Radiation therapy in hyperbaric oxygen for head and neck cancer at Royal Adelaide Hospital–1964 to 1980.¬†International journal of radiation oncology, biology, physics, 1987 Feb;13(2):201-8.¬†https://www.ncbi.nlm.nih.gov/pubmed/3818386