Savina, Yann, Sandra Leal, Pascal Zellner, François Becker, Monica Piris, and Emmanuel Cauchy. The effect of a 300 mbar increase in barometric pressure on digital microcirculation in healthy subjects exposed to high altitude: Is the use of a portable hyperbaric chamber to treat frostbite and/or hypothermia in the field indicated? (Flow_Pulse Study). High Alt Med Biol. 18:000-000, 2019. Hypothermia and frostbite occur when there is a significant decrease in central and peripheral body temperature in individuals exposed to cold windy conditions, often at high altitude or in a mountain environment. Portable hyperbaric chambers increase the barometric pressure and thereby the partial pressure of oxygen inside the chamber, and their use is a well-known treatment for altitude illness. This study aims to show that a portable hyperbaric chamber could also be used to treat hypothermia and frostbite in the field, when rescue or descent is impossible or delayed. During a European research program (SOS-MAM, Flow Pulse study) measurements were taken from 27 healthy nonacclimatized voluntary subjects (21 men, 6 women, mean age 41 ± 17) at an altitude of 3800 m (Chamonix Mountain Lab, Aiguille du Midi, France) right before and immediately after spending 1 hour in a portable hyperbaric chamber at 300 mbar. We measured digital cutaneous temperature (Tcut), digital cutaneous blood flow (Fcut), digital tissue oxygenation (TPO), blood oxygen saturation (SO), heart rate, and core temperature. Air temperature inside the chamber (Tchamb) was measured throughout the whole session. We observed significant increases in Tchamb: 9.3°C compared with the outside temperature, Tcut: +7.5°C (±6.2°C 71%), Fcut: +58 (±89) (+379%), TPO: +18 mmHg (±11.9) (304%), and SO: 13%.

Savina, Leal, Zellner, Becker, Piris, Cauchy (2019). The Effect of a 300 mBar Increase in Barometric Pressure on Digital Microcirculation in Healthy Subjects Exposed to High Altitude: Is the Use of a Portable Hyperbaric Chamber to Treat Frostbite and/or Hypothermia in the Field Indicated? (Flow_Pulse Study). High altitude medicine & biology, 2019 Jan;():. https://www.ncbi.nlm.nih.gov/pubmed/30615485