Background
Primary Fibromyalgia Syndrome (PFMS) is a common chronic pain syndrome with an unknown etiology. Increased oxidative stress results from an imbalance between products of oxidation and antioxidant defenses. There are several clinical conditions associated with increased oxidative stress, but novel data suggest a relationship between oxidative stress and pain perception. Furthermore, there is little information available in scientific literature about oxidative and antioxidative parameters in PFMS. In the present study we examined the involvement of oxidative and antioxidative parameters in women with PFMS and also evaluated its correlation with the severity of its symptoms. Methods & Materials: Oxidative stress was determined by measuring the levels of Lipid Peroxides (LPO) and Protein carbonyl in plasma and antioxidative parameters like catalase, Glutathione peroxidase (GPx) and Glutathione Reductase (GR) in lysate in 60 female patients satisfying American College of Rheumatology (ACR) criteria for FMS and 60 healthy females without PFMS. Clinical parameters of PFMS were evaluated by Fibromyalgia Impact Questionnaire Revised (FIQR).
Fatima, Ghizal & Das, Siddharth & Mahdi, Abbas Ali. (2016). To evaluate the level of oxidative and antioxidative parameters and its relationship with clinical symptoms in women with Primary Fibromyalgia Syndrome. International Journal of Infectious Diseases. 45. 223. 10.1016/j.ijid.2016.02.504.