Hyperbaric oxygen (HBO) is used but unproven for many conditions, including burns. We hypothesized that HBO therapy might increase oxygen delivery to intestine during burn shock and decrease mucosal injury. University research laboratory. We studied the effects of HBO therapy (100% oxygen at 2.4 atm absolute) on mesenteric bacterial colonies (MBCs) in mice following 32% total body surface area burns. MBCs were counted 24 or 48 hours postburn by culturing mesenteric tissue. Intestinal histologic features were examined, acid-base balance was measured, and pulmonary neutrophil deposition was estimated by lung myeloperoxidase content. HBO delivered in a compression chamber.
Tenenhaus, Hansbrough, Zapata-Sirvent, Neumann, , , , , (1994). Treatment of burned mice with hyperbaric oxygen reduces mesenteric bacteria but not pulmonary neutrophil deposition. Archives of surgery (Chicago, Ill. : 1960), 1994 Dec;129(12):1338-42. https://www.ncbi.nlm.nih.gov/pubmed/7986166