The use of hyperbaric oxygen therapy is expanding as research continues to validate its use in a variety of chronic and acute illnesses. High-dose oxygen, delivered under pressures greater than sea level, enables the body to increase diffusion of oxygen into tissues and stimulates angiogenesis and the immune response. These effects improve overall wound healing for those suffering from radionecrosis, peripheral vascular disease, and a variety of complicated infections.

Shafer, , , , , , , , (1993). Use of hyperbaric oxygen as adjunct therapy to surgical debridement of complicated wounds. Seminars in perioperative nursing, 1993 Oct;2(4):256-62. https://www.ncbi.nlm.nih.gov/pubmed/8054952