Hyperbaric oxygen may provoke lesions in various organs and tissues depending on the dose and application time. The toxic action mechanisms of oxygen are manifold. The pulmonary lesions that occur in mice submitted to various oxygen pressures are investigated. Anatomo-pathological examination revealed numerous alterations of various kinds depending on pressure used. Emphysema, pulmonary oedema and enormous inflammatory processes in the lung are the most frequent findings encountered in research.

Cerrati, Italiano, , , , , , , (1976). [Various pulmonary lesions induced by high-pressure oxygen]. Minerva medica, 1976 May;67(24):1561-6. https://www.ncbi.nlm.nih.gov/pubmed/934510