The value of misonidazole in advanced head and neck cancer was examined in 3 ways and the preliminary results are reported in a randomized study with large fractions of irradiation, when misonidazole appeared to confer no advantage; whereas in previously (partially) treated patients misonidazole was possibly useful. The combination of hyperbaric oxygen and misonidazole did not appear to be toxic.

Sealy, , , , , , , , (1978). A preliminary clinical study in the use of misonidazole in cancer of the head and neck. The British journal of cancer. Supplement, 1978 Jun;3():314-7. https://www.ncbi.nlm.nih.gov/pubmed/277253