Some practitioners advocate hyperbaric oxygen (HBO2) for sequelae following brain injury. This study assessed recruitment, tolerance and safety in preparation for a randomized clinical trial. Prospective, open-label feasibility study. Hyperbaric medicine department of a tertiary academic hospital. Participatory adult outpatients with problems from stroke (n=22), anoxia (13) or trauma (28) that occurred at least 12 months before enrollment, without contraindications to HBO2. Sixty-three participants enrolled in the study (21 females,42 males). Age was 45 +/- 16 years (18-76) and time from injury was 6.9 +/- 7.1 years (1.0-29.3). Fifty-three completed the study intervention, and 55 completed the assessment battery.

Churchill, Weaver, Deru, Russo, Handrahan, Orrison, Foley, Elwell, (). A prospective trial of hyperbaric oxygen for chronic sequelae after brain injury (HYBOBI). Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, ;40(2):165-93. https://www.ncbi.nlm.nih.gov/pubmed/23682548