Abstract: Tumor hypoxia has proven prognostic impact in head and neck cancers and is associated with poor response to radiotherapy. Hyperbaric oxygenation (HBO) offers an approach to overcome hypoxia. We have performed pO2 measurements in selected patients with head...
Cancer
Hyperbaric Oxygen Therapy (HBOT) Research for Cancer.
The effects of radiotherapy on maxillofacial tissue.
Abstract: Radiation therapy for the treatment of maxillofacial tumours can lead to delayed complications. One of the most severe complications is osteoradionecrosis (ORN), which can cause orocutaneous fistulae, exposed mandible and considerable pain. The condition can...
Multidisciplinary management of a Jehovah’s Witness patient for the removal of a renal cell carcinoma extending into the right atrium.
Abstract: To highlight the management of a Jehovah's witness surgical patient presenting for cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest. A 47-yr-old male, Jehovah's Witness, with renal cell carcinoma was admitted for left radical nephrectomy...
A survey of antibiotic prescribing by maxillofacial consultants for dental extractions following radiotherapy to the oral cavity.
Abstract: To analyse the antibiotic prescribing trends for exodontia and minor oral surgery in patients with a history of radiotherapy. Also, to evaluate the use of hyperbaric oxygen as a separate modality in the prevention of osteoradionecrosis. A survey of...
Comparison of 5-aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study.
Abstract: Photosan, a mixture of porphyrin oligomers as sensitizer for photodynamic therapy (PDT), carry the risk of prolonged photosensitivity of the skin. New sensitizer such as 5-aminolaevulinic acid (ALA) with low rates of skin phototoxicity appear to be promising...
ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects.
Abstract: Mutation of the ATM gene may be associated with enhanced radiosensitivity and increased radiation-induced morbidity. Denaturing high performance liquid chromatography (DHPLC) is a powerful new technique proven to be sensitive and accurate in the detection of...
[Delayed radiation-induced optic neuropathy in patients with tumors in the chiasmal-sellar area after radiation therapy].
Abstract: Six clinical observations of a rare condition, delayed radiation-induced optic neuropathy (RON) are presented. RON developed in patients with brain tumors treated by radiotherapy and radiosurgery; in the majority of patients the condition developed during...
Cerebral arterial gas embolism following diagnostic bronchoscopy: delayed treatment with hyperbaric oxygen.
Abstract: To describe a clinical scenario consistent with the diagnosis of cerebral arterial gas embolism (CAGE) acquired during an outpatient bronchoscopy. Our discussion explores the mechanisms and diagnosis of CAGE and the role of hyperbaric oxygen therapy. A...
Does new photosensitizer improve photodynamic therapy in advanced esophageal carcinoma?
Abstract: Polyhematoporphyrin (Photosan) as sensitizers for photodynamic therapy (PDT) in advanced esophageal cancer carry the risk of prolonged photosensitivity of the skin. New sensitizers such as 5-aminolaevulinic acid (ALA) with low rates of skin phototoxicity...
