Cancer is common and radiotherapy is one well-established treatment for some solid tumours. HBO may improve the ability of radiotherapy to kill hypoxic cancer cells, so the administration of radiotherapy while breathing HBO may result in a reduction in mortality and tumour recurrence. To assess the benefits and harms of radiotherapy while breathing HBO. In November 2004 we searched The Cochrane Central Register of Controlled Trials (CENTRAL), (The Cochrane Library Issue 3), MEDLINE, EMBASE , CINAHL, DORCTHIM and reference lists of articles. Relevant journals were handsearched. Randomised and quasi-randomised studies comparing the outcome of malignant tumours following radiation therapy while breathing HBO versus air (with or without sham therapy).

Bennett, Feldmeier, Smee, Milross, , , , , (2005). Hyperbaric oxygenation for tumour sensitisation to radiotherapy. The Cochrane database of systematic reviews, 2005 Oct;(4):CD005007. https://www.ncbi.nlm.nih.gov/pubmed/16235387