Dental implants offer one way to replace missing teeth. Patients who have undergone radiotherapy and those who have also undergone surgery for cancer in the head and neck region may particularly benefit from reconstruction with implants. Hyperbaric oxygen therapy (HBO) has been advocated to improve the success of implant treatment in patients who have undergone radiotherapy but this remains a controversial issue. To compare the success, morbidity, patient satisfaction and cost effectiveness of dental implant treatment carried out with and without HBO in irradiated patients. The following electronic databases were searched: the Cochrane Oral Health Group’s Trials Register (to 17 June 2013), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2013, Issue 5), MEDLINE via OVID (1946 to 17 June 2013) and EMBASE via OVID (1980 to 17 June 2013). No restrictions were placed on the language or date of publication when searching the electronic databases. We checked the bibliographies of relevant clinical trials and review articles for studies outside the searched journals. We wrote to authors of the identified randomised controlled trials (RCTs) and to more than 55 oral implant manufacturers; we used personal contacts and we made a request on an internet discussion group in an attempt to identify unpublished or ongoing RCTs. Randomised controlled trials (RCTs) of HBO therapy for irradiated patients requiring dental implants.

Esposito, Worthington, , , , , , , (2013). Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants. The Cochrane database of systematic reviews, 2013 Sep;(9):CD003603. https://www.ncbi.nlm.nih.gov/pubmed/24085641