The cytologic effects of radiation therapy involve all tissues and most significantly bone within the treated area. Of greatest concern is the permanence of the compromised healing and resistance to infection of the irradiated tissues. Those dental procedures that do not cause tissue trauma are considered nonrisk. Any procedure that traumatizes previously irradiated tissues can exceed the healing potential of the compromised tissue and frequently results in an uncontrollable necrosis. The adequate utilization of hyperbaric oxygen therapy has been shown to be 95% effective in preventing osteoradionecrosis in postirradiated tissues.

Fleming, , , , , , , , (1990). Oral tissue changes of radiation-oncology and their management. Dental clinics of North America, 1990 Apr;34(2):223-37. https://www.ncbi.nlm.nih.gov/pubmed/2140101