Radiation therapy under the conditions of hyperbaric oxygenation (HBO) using the method of mean fractionation (3.3 Gy 3 times a week up to the summary dose of 33 Gy) was employed to overcome tumor hypoxia and to raise selectively radiosensitivity of laryngeal cancer. A randomized study of 120 patients has shown that the use of radiation therapy under HBO conditions makes it possible to reduce the frequency of radiation reactions, to increase tumor resorption and the degree of radiation damage, to reduce the frequency of postoperative purulent complications, and to prevent the occurrence of early and late recurrences and metastases.

Dar’ialova, Bitiutskiĭ, Sukirko, Klochikhin, Frank, , , , (1985). [Preoperative irradiation of laryngeal cancer patients under different oxygen regimens]. Meditsinskaia radiologiia, 1985 Sep;30(9):10-5. https://www.ncbi.nlm.nih.gov/pubmed/2995755