The management of pyoderma gangrenosum often requires systemic drug therapy, such as corticosteroids, sulfones, or immunosuppressants, either alone or in combination. Inconsistent response to therapy is a source of frustration to both patient and physician. Several reports in the literature document the successful treatment of pyoderma gangrenosum with hyperbaric oxygen therapy. In our patient, a woman with severe rheumatoid arthritis and diabetes mellitus, hyperbaric oxygen therapy not only promoted healing of pyoderma gangrenosum but permitted reduction of systemic corticosteroids.

Wasserteil, Bruce, Sessoms, Guntupalli, , , , , (1992). Pyoderma gangrenosum treated with hyperbaric oxygen therapy. International journal of dermatology, 1992 Aug;31(8):594-6. https://www.ncbi.nlm.nih.gov/pubmed/1428456