The effect of hyperbaric oxygenation (HBO) used in the pre- and postoperative periods on the content of lipid peroxidation (LPO) products in the plasma and erythrocyte membranes and on the physiological antioxidant activity has been assessed in patients with lung cancer. It has been shown that hypoxia in patients with lung cancer is accompanied by LPO activation and decreased antioxidant protection. Surgery increases hypoxia and further activates LPO. HBO has a positive effect on LPO processes manifested in a decrease of secondary LPO products content and mobilization of antioxidant activity, i.e. protects the cellular membrane from hypoxia-induced damages, promotes a 1.5-fold reduction in the incidence of postoperative complications, and enhances the efficacy of surgical treatment of patients with lung cancer.
Nikolaeva, Stepanenko, Chubukhchiev, , , , , , (). [The effect of hyperbaric oxygenation on the indices of lipid peroxidation in the blood of patients with lung cancer]. Anesteziologiia i reanimatologiia, ;(4):67-8. https://www.ncbi.nlm.nih.gov/pubmed/1952246