Because vascularity is severely compromised following radiation therapy, aseptic necrosis with secondary infection and extensive bone destruction can result in an advanced state of osteoradionecrosis. Transoral mandibulectomy is an excellent method for dealing with this difficult problem. This article discusses technical aspects of the procedure as well as applied anatomy and a case report. Evidence in the recent literature concerning hyperbaric oxygen therapy is very encouraging.

Klein, , , , , , , , (). Transoral mandibulectomy in advanced osteoradionecrosis. Head & neck surgery, ;2(2):160-4. https://www.ncbi.nlm.nih.gov/pubmed/264109