To evaluate the efficacy of hyperbaric oxygen therapy in treatment of severe refractory radiation-induced hemorrhagic proctitis. Nine patients with median age 75 (range, 66-83) treated with hyperbaric oxygen (HBO) at University of Cincinnati were reviewed. Pre- and post-therapy bleeding was graded on a 5-point scale. Five patients had previous hospitalizations for anemia and required transfusions. Three patients had undergone electrocautery or argon plasma coagulation before hyperbaric oxygen therapy (HBOT). The remainder had medical therapy before HBO. No patients experienced resolution of symptoms before HBO. The median follow-up after HBO was 17 months (range, 1-77). Seven patients had complete resolution of rectal bleeding. Two patients exhibited a partial response, but continued to experience intermittent bleeding. The Wilcoxon signed rank test determined that HBOT significantly reduced rectal bleeding. HBOT is a very effective treatment of hemorrhagic radiation-induced proctitis.

Girnius, Cersonsky, Gesell, Cico, Barrett, , , , (2006). Treatment of refractory radiation-induced hemorrhagic proctitis with hyperbaric oxygen therapy. American journal of clinical oncology, 2006 Dec;29(6):588-92. https://www.ncbi.nlm.nih.gov/pubmed/17148996