The utilization of various radiomodifiers (hyperbaric oxygenation, metronidazole and their combination, tourniquet and total body gas hypoxia, unconventional dose fractionation) in radiation therapy of over 2000 cancer patients with tumors of the main sites made it possible to raise therapeutic efficacy using a differentiated approach to a choice of therapeutic tactics with relation to radiobiological specificities. The results obtained made it possible to determine the prospects of a further study of the efficacy of the utilization of HBO and MZ and their combination. Tourniquet hypoxia in view of a narrow range of indications and danger of a tumor protection effect should be abandoned. As to the hypoxic gas breathing mixture containing 10% O2 the absence of such an effect must be proved. Unconventional fractionation is no less promising, and as distinct from radiomodifiers it does not require extra resources or special equipment. The use of large fractions to enhance an antitumor effect, their combination in different succession with small fractions to lessen normal tissue damage as well as superfractionation with relation to tumor oxygen supply, possible reoxygenation, a capacity for repopulation and reparation can ensure at present a true therapeutic advantage.
Kiseleva, Dar’ialova, Kvasov, Pitskhelauri, Sukirko, , , , (1986). [Use of radiomodifiers during radiotherapy of patients with malignant tumors]. Meditsinskaia radiologiia, 1986 Feb;31(2):17-21. https://www.ncbi.nlm.nih.gov/pubmed/3951343