Abstract Higher rates of serious illness and death from coronavirus SARS-CoV-2 (COVID-19) infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental...
Glutathione
Cognitive Improvement with Glutathione Supplement in Alzheimer’s Disease: A Way Forward
Abstract Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people worldwide. The actual cause of AD is still unknown. Oxidative stress is believed to be important player in AD pathology. Glutathione (GSH) is a major...
Glutathione: Antioxidant Properties Dedicated to Nanotechnologies
Abstract Which scientist has never heard of glutathione (GSH)? This well-known low-molecular-weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in GSH should not be restricted to its redox properties. This multidisciplinary review...
The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?
Abstract Significance:Â Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes,...
Psoriasis Improvement in Patients Using Glutathione-enhancing, Nondenatured Whey Protein Isolate: A Pilot Study
Abstract Background: Psoriasis is a common autoimmune disease with enhanced systemic inflammation and heightened levels of oxidative stress. Glutathione is the major antioxidant in human cells. Objectives: To determine if a nondenatured bioactive whey protein isolate...
Glutathione: overview of its protective roles, measurement, and biosynthesis
Abstract This review is the introduction to a special issue concerning, glutathione (GSH), the most abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles in protecting cells from oxidative damage and the toxicity of xenobiotic...
The central role of glutathione in the pathophysiology of human diseases
Abstract Reduced glutathione (L-gamma-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first, the formation of gamma-glutamylcysteine from glutamate and cysteine,...
The Diverse Benefits of Glutathione: A Key Antioxidant for Reversing Chronic Illness
Abstract The diverse health benefits of the antioxidant peptide glutathione have attracted the attention of bioscience researchers and practitioners of alternative and mainstream medicine. Preliminary studies indicate glutathione plays an important role in repairing...
The role of oxidants and antioxidants in psoriasis
Abstract Background: Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated erythema and scaly plaques. The pathogenesis of psoriasis still remains unclear. An increased reactive oxygen species (ROS) and insufficient antioxidant...